Alessio Fasano, MD, a world-renowned pediatric gastroenterologist and research scientist, has found all autoimmune conditions have three factors in common: a genetic susceptibility, environmental triggers and leaky gut.

Discover exactly how leaky gut leads to autoimmunity in this 90-second explainer video!


Leaky gut occurs when the tight junctions of your intestinal barrier open up, allowing unwanted particles to pass through.

This can be caused by gluten and other inflammatory foods, gut infections like SIBOCandida, and parasites, along with toxins, stress, and even medications that irritate your gut lining.

Once the barrier is open, bacteria, toxins, viruses, and food particles are able to escape your digestive tract and enter your bloodstream, where your immune system tags them as invaders and goes into attack mode.

This triggers a big spike in inflammation as your immune system works to neutralize all of the threats.

Over time, as your gut remains leaky and you become chronically inflamed, your immune system becomes too stressed and eventually misfires, attacking your own tissues and triggering autoimmunity.

However, if you restore your gut’s lining so it is no longer permeable, you can stop the inflammation and give your immune system a break to recover.

Ready for a comprehensive approach to reversing autoimmune disease for good?

Check out our Adaptation Program to see if it’s the right fit for you and book your free discovery call to get started!

About the Author: Dr. Seth Osgood is a Doctor of Nursing Practice, Board Certified Family Nurse Practitioner and Institute of Functional Medicine (IFM) Certified Practitioner.

He has helped people from around the world improve their health utilizing a Functional Medicine approach.

Want to work with Dr. Osgood and the GrassRoots team? Become a patient in our West Lebanon, New Hampshire Functional Medicine clinic, or our Burlington, Vermont Functional Medicine clinic!